امروز شنبه , 03 شهریور 1403
شنبه تا پنج شنبه - 9 صبح الی 20 عصر
دانلود مقاله : Personalized medicine: A paradigm shift in healthcare 2013
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دانلود مقاله :
Personalized medicine: A paradigm shift in healthcare 2013
نویسندگان :
Wen-Ling Liao , Fuu-Jen Tsai
فرمت:pdf
چکیده :
Personalized medicine is based on the established principle that each individual is born
with unique biological characteristics. Genomics, the science of studying the genes in a
genome and their interactions with each other, forms the foundation of personalized
medicine. Several genomic methods are currently used to identify susceptibility loci for
diseases or phenotypic traits, namely, linkage analysis, candidate gene association studies,
and genome-wide association studies. The success of personalized medicine depends on
having accurate diagnostic tests capable of identifying patients who can benefit from
targeted therapy. Larger cohort studies plus the application of genome-wide association
studies offer great potential for identifying the genetic factors that influence the pharmacology
of specific drugs. By combining these approaches, physicians can predict health
risks, determine and quantify the dynamics of disease development, and tailor therapeutic
protocols to the needs of the individual. In this review, we focus on the effect of genetic
profiling on disease outcomes as well as the potential of genomic methods to predict
disease and drug response
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